HIV hub sample catalogue
The HIV hub stores biological material from patients which are grouped into 7 prospective longitudinal cohorts of HIV-patients with defined characteristics.
| HIV+ patient cohorts | Criteria for cohort inclusion |
| HIV-infected adult cohort (CoRIS): |
Includes patients over the age of 13 with a confirmed diagnosis of HIV infection that have not received prior antiretroviral treatment and are being seen for the first time in the participating centre
|
| Rapid progressors cohort | Includes patients whose CD4+ T-cell levels have fallen below 350 lymphocytes or patients who are diagnosed with AIDS before the end of the third year after their documented seroconversion date (and beyond the first 3 months) and with a window of fewer than 2 years between the last negative and first positive test, always in the absence of ART. |
| Long Term Non-Progressors cohort (LTNP-RIS) | includes patients who have had > 500/μL CD4+ T-cell count and <10,000 HIV-RNA copies/ml viral load for over 10 years, in the absence of ART. |
| HIV Controller cohort (EC-RIS) | ART-naive patients who have been HIV+ for more than 12 months with at least two viral load determinations during such period. Elite controllers: <50 HIV-RNA copies/ml Viral controllers: individuals within this range: >50 – <2000 copies/ml. |
| Acute/recent infection cohort (PHI-RIS) | Acute infection: Patients within the first three months after documented seroconversion date
Recent infection: Patients within the first six months after documented seroconversion date |
| Vertical transmission cohort (CoRISpe) | HIV patients infected by vertical transmission |
| Hepatitis C (HCV) and HIV Co-infection cohort (HIV-HCV coinfection cohort) | HIV-HCV coinfected patients |
This table shows the biological material available for each of the cohorts described in the previous section.
| HIV+ individuals cohort | Blood | Plasma | Serum | Cell Pellet | PBMC | DNA | Liver
Biopsies |
Spleen
PBMC |
Faeces |
| CoRIS | yes | yes | — | yes | yes | yes | — | — | — |
| Rapid progressors cohort | yes | yes | — | yes | yes | yes | — | — | — |
| LTNP-RIS | yes | yes | — | yes | yes | yes | — | — | — |
| EC-RIS | yes | yes | — | yes | yes | yes | — | — | — |
| PHI-RIS | yes | yes | — | yes | yes | yes | — | — | — |
| CoRISpe | yes | yes | yes | yes | yes | yes | — | — | yes |
| Individuals with
HIV-HCV coinfection
|
yes | yes | — | yes | yes | yes | yes | yes | — |
Hospital hub sample catalogue
| Cohorts | Blood | Plasma | Serum | Cell Pellet | PBMC | DNA | Nasal brushing sample | Brain
glioma |
| Respiratory conditions
(patients with bronchiolitis) |
yes | yes | — | — | — | yes | yes | — |
| Neonatology (patients with early-onset sepsis) | yes | yes | — | — | yes | yes | — | — |
| Endocrinology (patients with hypothyroidism) | yes | yes | — | — | — | yes | — | — |
| Oncology (children with neutropenia) | yes | yes | — | — | yes | yes | — | — |
| Oncology (patients with colorectal cancer) | yes | yes | — | — | yes | yes | — | — |
| Oncology (patients who have been diagnosed with glioma) | — | — | yes | — | — | — | — | yes |
| Rare diseases (sufferers from surfactant protein deficiency, DiGeorge syndrome, “Candle” syndrome, osteomyelitis of the coccyx, Shwachman–Diamond syndrome or Rosai-Dorfman disease (RD), aka sinus histiocytosis. | yes | yes | — | — | yes | yes | — | — |
| Rare diseases (fetal -hemoglobine sickle-cell disease) | yes | yes | — | yes | yes | yes | — | — |
| Infectious diseases (whooping cough sufferers) | yes | — | — | — | — | — | yes | — |
| Infectious diseases (TB sufferers) | yes | yes | — | — | yes | yes | — | — |
| Healthy donors (Buffy coat) | yes | yes | — | yes | yes | yes | — | — |
